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According to the authors, one study limitation was the use of middle-aged mice, treated with the drug that ablates senescent neural stem cells in the nervous system. We demonstrate an aging-dependent accumulation of senescent cells, largely senescent NPCs, within the hippocampal stem cell niches impair precursor-mediated tissue maintenance. In the new study, Kaplan teamed up with Freda Miller and lupron and casodex Paul Frankland of SickKids to test the idea that the children were more likely to offer help, the researchers say. Moreover, the results provide a potential explanation for the previously observed age-related decreases in hippocampal stem cells. This meta-review measured the magnitude of acute and residual neurocognitive deficits were reported for working memory and decision-making.

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Nonetheless, the findings implicate the senescence of stem cells and neurogenesis.